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Gene, Chromosomes, and Disease: From Simple Traits, to Complex Traits, to Personalized Medicine

By Nicholas Wright Gillham

Published by FT Press

Published Date: Mar 15, 2011

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This very readable overview of the rise and transformations of medical genetics and of the eugenic impulses that have been inspired by the emerging understanding of the genetic basis of many diseases and disabilities is based on a popular nonmajors course, "Social Implications of Genetics," that Gillham gave for many years at Duke University. The book is suitable for use as a text in similar overview courses about genes and social issues or genes and disease. It gives a good overview of the developments and status of this field for a wide range of biomedical researchers, physicians, and students, especially those interested in the prospects for the new, genetics-based personalized medicine.

Table of Contents

Preface     ix

Chapter 1: Hunting for disease genes     1

Chapter 2: How genetic diseases arise     25

Chapter 3: Ethnicity and genetic disease     55

Chapter 4: Susceptibility genes and risk factors     81

Chapter 5: Genes and cancer     103

Chapter 6: Genes and behavior     129

Chapter 7: Genes and IQ: an unfinished story     151

Chapter 8: Preventing genetic disease     175

Chapter 9: Treating genetic disease     199

Chapter 10: The dawn of personalized medicine     235

Postscript: a cautionary note     249

References and notes     253

Glossary     293

Some useful human genetics Web sites     307

Acknowledgments     309

About the author     311

Index     313