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Mind, Brain, and Drug: An Introduction to Psychopharmacology

By Dawson Hedges, Colin Burchfield

Published by Pearson

Published Date: Sep 12, 2005

Table of Contents

Preface

 

I. THE NEUROBIOLOGICAL BASIS OF PSYCHOTROPIC DRUG ACTION AND BIOLOGY OF MENTAL DISORDERS

1. Neurons, Synapses, and the Brain: A Brief Introduction to Neuroscience

The Neuron       

            The Cell body

            Receptors

            Dendrites

            Axons

            The Action Potential

            Types of Neurons

The Synapse

Neuroglial Cells

Overview of Neuroanatomy

Peripheral Nervous System

            Somatic Nervous System

            Autonomic Nervous System

Central Nervous System

Summary

Study Questions

2. Neurotransmitters and Receptors

Neurotransmitters and Their Receptors

Serotonin

Norepinephrine

Dopamine

Acetylcholine

Gamma Amino Benzoic Acid

Glutamate

Opioid Neuropeptides

Melatonin

Summary         

Study Questions

3. Pharmacokinetics and Pharmacodynamics

Pharmacokinetics

            Route of Administration

            Absorption

            Distribution       

            Metabolism and Elimination

            Drug Half-Life and Steady State

Pharmacodynamics

            Potency and Efficacy

            Dose-Response Curves

Drug Concentration Measurement

Tolerance and Dependence

Summary

Study Questions

4. The Biology of Mental Disorders

Affective Disorders        

Anxiety Disorders

            Generalized Anxiety Disorder

            Obsessive-Compulsive Disorder

            Posttraumatic Stress Disorder

            Panic Disorder

            Social Phobia               

Schizophrenia

Attention-Deficit, Hyperactivity Disorder

Summary

Study Questions

II. THE PSYCHOTROPIC DRUGS: THEIR PHARMACOLOGY, METABOLISM, INTERACTIONS, ADVERSE EFFECTS, AND THERAPEUTIC USES

5. Sedative Hypnotics, Anxiolytics, and Alcohol

Barbiturates and Related Compounds

Benzodiazepines

Sodium Oxybate

Zolpidem and Zaleplon

Pregabalin

Buspirone

Alcohol

Summary

Study Questions

6. The Psychostimulants, Amphetamines, Cocaine, Caffeine, and Nicotine

Methylphenidate), Pemoline, and Phentermine

Modafinil

The Amphetamines

Cocaine

Atomoxetine

Uses of Methylphenidate, Pemoline, Phentermine, Modafinil, Atomoxetine, and the Amphetamines

Nicotine

Caffeine

7. The Opiates

Mechanism of Action, Pharmacology, and Metabolism

Exogenous Opiates

Adverse Effects

Uses  

Management of Opiate Detoxification and Withdrawal

Treatment of Opiate Addiction

Summary

Study Questions

8. Marijuana, Hallucinogens, Phencyclidine, and Inhalants   

Marijuana

The Hallucinogens

Phencyclidine

The Inhalants

Summary

Study Questions

9. The Antidepressants

Tricyclic Antidepressants

Monoamine Oxidase Inhibitors

Specific Serotonin Reuptake Inhibitors

Atypical and Dual-Action Antidepressants

            Bupropion

            Mirtazapine

            Trazodone and Nefazodone

            Venlafaxine

            Duloxetine

            Reboxetine

Other Putative Mechanisms of Antidepressant Action

Summary

Study Questions

10. The Mood Stabilizers

Lithium

Carbamazepine

Valproic Acid

Lamotrigine

Gabapentin

Other Anticonvulsant Mood Stabilizers

            Topiramate

            Tiagabine

Other Non-anticonvulsant Mood Stabilizers

Summary

Study Questions

11. First and Second Generation Antipsychotics

Typical or First-Generation Antipsychotics

Atypical or Second-Generation Antipsychotics

Drugs Used in the Treatment of Extrapyramidal Effects

Summary

Study Questions           

12. The Neurobiology and Treatment of Dementia

The Neurobiology of Dementia

            Alzheimer’s Dementia

            Dementia with Lewy bodies

            Vascular Dementia

            Frontal-Temporal Dementia

            Other Dementias

Cognitive Enhancers

            Acetylcholinesterase Inhibitors

                        Tacrine

                        Donepezil

                        Rivastigamine

                        Galantamine

            Other Approaches to the Treatment of Dementia

Summary

Study Questions                       

13. St. John’s Wort, Gingko, Kava, Steroids, and Valerian

St. John’s Wort

Ginkgo

Kava

Valerian

Summary

Study Questions           

Appendix 1: Electroconvulsive Therapy, Vagal Nerve Stimulation, and Transcranial Magnetic Stimulation

Electroconvulsive Therapy

Transcranial Magnetic Stimulation

Vagal Nerve Stimulation

Summary

Study Questions

Appendix 2: List of Alphabetized Generic Drug Names (with Trade Names in Parentheses)


Appendix 3: List of Alphabetized Trade Drug Names (with Generic Names in
Parentheses)


Glossary

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Mind, Brain, and Drug: An Introduction to Psychopharmacology

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