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Mobile DNA: Finding Treasure in Junk

By Haig H. Kazazian

Published by FT Press

Published Date: Mar 21, 2011

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Description

This book thoroughly reviews our current scientific understanding of the significant role that mobile genetic elements play in the evolution and function of genomes and organisms–from plants and animals to humans. Highly-regarded geneticist Haig Kazazian offers an accessible intellectual history of the field’s research strategies and concerns, explaining how advances opened up new questions, and how new tools and capabilities have encouraged progress in the field.

 

Kazazian introduces the key strategies and approaches taken in leading laboratories (including his own) to gain greater insight into the large proportion of our genome that derives from mobile genetic elements, including viruses, plasmids, and transposons. He also presents intriguing insights into long-term research strategies that may lead to an even deeper understanding.

Table of Contents

Preface: Thoughts on Doing Science     xii

Chapter 1        Introduction to Mobile DNA     1

Chapter 2        Varieties of Mobile DNA     5

Chapter 3        DNA Transposons     19

Chapter 4        Mobile DNA of Model Organisms     29

Chapter 5        Exceptional Scientists Working on Mobile DNA in Lower Organisms     35

Chapter 6        Role of Bioinformatics in Genome Analysis     43

Chapter 7        The Prologue     49

Chapter 8        “Welcome to the Wonderful World of LINEs”     59

Chapter 9        An Experimental Breakthrough     73

Chapter 10      Reverse Transcriptase to the Rescue     81

Chapter 11      A Quirk of L1 Elements–A Lousy 3’ End Is Important for Genome Evolution     85

Chapter 12      A Tour de Force from Tom Eickbush     89

Chapter 13      “I don’t believe all those colonies represent retrotransposition events.”     93

Chapter 14      L1 Encodes an Endonuclease     101

Chapter 15      The Jocks     105

Chapter 16      The Mayor and the Frenchman     115

Chapter 17      Ostertag’s Coups     121

Chapter 18      The Independent Canadian     133

Chapter 19      The Musician Scientist     141

Chapter 20      Young Ladies in the Back Bay     145

Chapter 21      The Brilliant Young Lady from China     157

Chapter 22      Hiroki’s Big Surprises     163

Chapter 23      A Young Man with a Purpose     173

Chapter 24      Other Mobile DNA in Mammalian Genomes     179

Chapter 25      Effects of Retrotransposons on Mammalian Genomes     187

Chapter 26      Host Factors Involved in L1 Retrotransposition     201

Chapter 27      Why Mobile DNA?     207

Chapter 28      The Future of Mobile DNA Research     209

Chapter 29      Predictions for Mobile DNA     221

References     225

Glossary     249

Index     255

Purchase Info

ISBN-10: 0-13-257520-5

ISBN-13: 978-0-13-257520-1

Format: Safari PTG

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